Exploration of the application of the sprayed γ-GGT fluorescent probe for visual imaging of epithelial ovarian cancer. This is an ASCO Meeting Abstract from the ASCO Breakthrough: A Global Summit for ...

TP53 mutations are crucial in cancer development and treatment response, influenced by genetic and environmental factors. In CLL and AML, TP53 serves as a significant prognostic marker, affecting ...

In mantle cell lymphoma (MCL), an aggressive form of B-cell non-Hodgkin lymphoma, TP53 mutations are known to affect patients’ prognosis—but questions remain. What does the heterogeneity of TP53 ...

p53 mutants are among the most common protein variants expressed in cancer cells. Classifying TP53 status in human cancer as ‘inactivated’ or ‘loss-of-function’ is misleading. Many mutant p53 variants ...

The TP53 is a gene that instructs the cell to produce tumor protein (p53) ; a vital transcription factor and tumor suppressor. P53 is known as the “guardian of the genome” as it helps in regulating ...

TP53 is a gene located on chromosome 17 that, when normal, stops cells from growing and dividing. You can inherit a TP53 mutation from your parents or develop one later in life. An inherited TP53 ...

What is TP53 and what role does it play in cancer? Medically reviewed by Marla Anderson, MD The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations ...

Research at MSK Our research impact Research topics Core facilities & resources ...

Panel A shows Kaplan–Meier estimates of overall survival and progression-free survival among 34 patients with chronic lymphocytic leukemia with TP53 alterations who were treated with ibrutinib as ...

Impact of Expert Pathologic Review of Lymphoma Diagnosis: Study of Patients From the French Lymphopath Network Multiple driver mutations are less common in NSCLC, and their prognostic and predictive ...