Scientists from Johns Hopkins and the University of Wisconsin have discovered that a protein called Sir2, which is found in nearly all living cells, has a new function that might help explain how ...

The enzyme sirtuin 6, or SIRT6, serves many key biological functions in regulating genome stability, DNA repair, metabolism and longevity, but how its multiple enzyme activities relate to its various ...

Sirtuins are NAD +-dependent enzymes that modulate the activities of target proteins, mediate changes in the metabolic status of cells and regulate diseases of ageing, including neurodegeneration, ...

Sirtuin genes and the proteins they encode were already linked to longevity in yeast. Now, a previously overlooked member of the family has excited researchers who study aging At last, a member of the ...

Franklin H. Epstein, M.D., served the New England Journal of Medicine for more than 20 years. A keen clinician, accomplished researcher, and outstanding teacher, Dr. Epstein was Chair and Professor of ...